GNA
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GNA全名Glycerol nucleic acid，中文直譯甘油核酸。是一種與DNA或RNA相似的化學(xué)物質(zhì)，但組成物有所不同。并不存在任何目前已知的自然界生物體內(nèi)。
GNA的骨架是由許多重復(fù)的甘油（DNA與RNA為五碳糖）經(jīng)由磷酸酯鍵的連結(jié)所組成。雖然甘油分子只有3個(gè)碳原子，但GNA仍然可比表現(xiàn)出沃森-克-{里}-克堿基配對(duì)（A對(duì)T；G對(duì)C），而且比起DNA與RNA，GNA的堿基配對(duì)更為穩(wěn)定，需要較高的融解溫度（Tm）才能解開(kāi)。
參考文獻(xiàn)
- Zhang Lilu, Peritz Adam, Meggers Eric. A simple glycol nucleic acid. J Am Chem Soc. 2005, 127 (12): 4174-5. PMID 15783191.
- Seita, Tooru; Yamauchi, Kiyoshi; Kinoshita, Masayoshi; Imoto, Minoru. Condensation polymerization of nucleotide analogues. Die Makromolekulare Chemie (1972), 154:255-261.
- Ueda, Nasuo; Kawabata, Toshio; Takemoto, Kiichi. Synthesis of N-(2,3-dihydroxypropyl) derivatives of nucleic bases. Journal of Heterocyclic Chemistry (1971), 8(5), 827-9.
- Acevedo, Oscar L.; Andrews, Robert S. Synthesis of propane-2,3-diol combinatorial monomers. Tetrahedron Letters (1996), 37(23), 3931-3934.
- Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Synthesis of acyclic oligonucleotides as antiviral and antiinflammatory agents and inhibitors of phospholipase A2. PCT Int. Appl. (1995), 126 pp. WO 9518820 A1 19950713 CAN 124:30276 AN 1995:982328
- Cook, Phillip Dan; Acevedo, Oscar L.; Davis, Peter W.; Ecker, David J.; Hebert, Normand. Preparation of ethylene glycol phosphate linked oligodeoxyribonucleotides as phospholipase A2 inhibitors. U.S. (1999), 39 pp., Cont.-in-part of U.S. Ser. No. 179,970. CODEN: USXXAM US 5886177 A 19990323 CAN 130:237811 AN 1999:205354
外部連結(jié)
- Meggers Laboratory
- Simpler than DNA - Chemical and engineering news
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參考來(lái)源
出自A+醫(yī)學(xué)百科 “GNA”條目 http://microbiomewatersummit.com/w/GNA 轉(zhuǎn)載請(qǐng)保留此鏈接
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